Acute Lymphoblastic Leukemia, Adult

Acute Lymphoblastic Leukemia, Adult

Treatment Options for Adult Acute Lymphoblastic Leukemia

In This Section
  • Untreated Adult Acute Lymphoblastic Leukemia
  • Adult Acute Lymphoblastic Leukemia in Remission
  • Recurrent Adult Acute Lymphoblastic Leukemia

For information about the treatments listed below, see the Treatment Option Overview section.

Untreated Adult Acute Lymphoblastic Leukemia

Standard treatment of adult acute lymphoblastic leukemia (ALL) during the remission induction phase includes the following:

  • Combination chemotherapy.
  • Tyrosine kinase inhibitor therapy with imatinib mesylate, in certain patients. Some of these patients will also have combination chemotherapy.
  • Supportive care including antibiotics and red blood cell and platelet transfusions.
  • CNS prophylaxis therapy including chemotherapy (intrathecal and/or systemic) with or without radiation therapy to the brain.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Adult Acute Lymphoblastic Leukemia in Remission

Standard treatment of adult ALL during the post-remission phase includes the following:

  • Chemotherapy.
  • Tyrosine kinase inhibitor therapy with imatinib, nilotinib, or dasatinib.
  • Chemotherapy with stem cell transplant.
  • CNS prophylaxis therapy including chemotherapy (intrathecal and/or systemic) with or without radiation therapy to the brain.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Recurrent Adult Acute Lymphoblastic Leukemia

Standard treatment of recurrent adult ALL may include the following:

  • Combination chemotherapy followed by stem cell transplant.
  • Monoclonal antibody therapy (blinatumomab or inotuzumab ozogamicin) followed by stem cell transplant.
  • Low-dose radiation therapy as palliative care to relieve symptoms and improve the quality of life.
  • Tyrosine kinase inhibitor therapy with dasatinib for certain patients.

Some of the treatments being studied in clinical trials for recurrent adult ALL include the following:

  • A clinical trial of stem cell transplant using the patient's stem cells.
  • A clinical trial of targeted therapy.
  • A clinical trial of chimeric antigen receptor (CAR) T-cell therapy.
  • A clinical trial of new anticancer drugs.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Disclaimer The content used in the pages is sourced from the National Cancer Institute Website ( www.cancer.gov )
Content Details Source URL : https://www.cancer.gov/types